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KMID : 1134120130160030342
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Journal of Breast Cancer
2013 Volume.16 No. 3 p.342 ~ p.344
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Genomic Profiling Shows Increased Glucose Metabolism in Luminal B Breast Cancer
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Ueda Shigeto
Saeki Toshiaki
Takeuchi Hideki
Shigekawa Takashi
Matsuura Kazuo
Nakamiya Noriko
Sano Hiroshi
Shimada Hiroko
Hirokawa Eiko
Osaki Akihiko
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Abstract
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We had previously reported a close association between pathological response and the maximum tumor standardized uptake value (SUVmax) measured by 18F-fluorodeoxyglucose positron emission tomography prior to chemotherapy in estrogen receptor (ER)-positive breast cancer. We hypothesized that glucose hypermetabolism by luminal B tumors may result in chemotherapy responsiveness. Using a single-gene expression assay, TargetPrint® (Agendia) and a 70-gene expression classifier, MammaPrint® (Agendia), we divided 20 patients with ER-positive primary breast cancer into luminal A and luminal B subtypes and compared the tumor SUVmax value between the two groups. A significantly higher SUVmax was measured for luminal B tumors (n=10; mean±SD, 7.6±5.6) than for luminal A tumors (n=10; mean±SD, 2.6±1.2; p=0.01). Glucose hypermetabolism could help predict intrinsic subtyping and chemotherapy responsiveness as a supplement to ER, progesterone receptor, HER2, and Ki-67 histochemical scores.
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KEYWORD
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Breast neoplasms, Estrogen receptor, Fluorodeoxyglucose positron emission tomography, Glucose metabolism
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